CIRCALYS

CIRCALYS® is a natural active ingredient standardized in andrographolide, extracted from the leaves of green chiretta (Andrographis paniculata), a prominent detoxifying herb in Ayurvedic medicine. This potent compound effectively alleviates the effects of fatigue induced by the demands of modern lifestyles on both skin and mood. By regulating the skin's circadian rhythm, CIRCALYS® rejuvenates aging or tired keratinocytes, promoting a more youthful gene expression profile and influencing circadian modulators associated with essential cellular processes. This leads to prolonged cell vitality, decreased cellular damage, and enhanced skin rejuvenation. Additionally, CIRCALYS® enhances the "Brain-Skin" axis, fostering relaxation through the stimulation of oxytocin, endocannabinoid, and endorphin signaling pathways. Clinical trials conducted over 28 days on night or shift workers demonstrated that CIRCALYS® significantly diminishes visible signs of facial fatigue (such as eye bags, dark circles, under-eye wrinkles, and dull complexion) and mitigates the mood effects of fatigue, promoting a sense of well-being while reducing perceived stress and negative emotions, akin to a "yoga-like" effect. As a chrono-detoxifying agent, CIRCALYS® provides an invigorating "feel-good" effect.