NV CAFFEINE ECO

NV Caffeine ECO is an active ingredient encapsulated in biopolymer particles with a diameter greater than 200nm. Because it is a hydrophilic substance, caffeine tends to precipitate depending on its vehicle and may form nonredispersible agglomerates. Nanovetores’ encapsulation technology allows the stabilization of sensitive componentsfrom being formulated on their free form, improving their incorporation intocosmetics, making them more effective.

The continuous application of NV Caffeine ECO provides the activation of lipolysis with significant microcirculation and cellulite aspect improvement, and also improvement of hyperpigmentation and periorbital swelling (dark circles). Therefore, NV Caffeine ECO application versatility is an innovative tool for cosmetic formulations.

NV Caffeine ECO contains caffeine active, a potent measurements-reducing agent. Which in addition to is lipolytic activity, it stands out for its ability to combat ultraviolet(UV) damage, and thus protects the skin from photoaging, improving strength, resilience and skin elasticity. With astringent action, caffeine promotes skin balance and improves blood microcirculation.

Caffeine, an alkaloid from the methylxanthines group, which occurs naturally in coffee, tea and chocolate, with relevant effects on various cellular biochemical processes.

Some of these effects include:

- inhibition of phosphodiesterase and CAMP accumulation;

- reduction of the mutagenic effect of that induced by UV;

- antioxidant effects and influence on DNA repair.

Studys also show the caffeine’s protective booster effect in sunscreens, with spectral range between 244 and 295 nm, and increased chemical stability of the formula components, being these mechanisms responsible for its skin protection against photoaging caused by UV induction.

Caffeine also stands out among the substances that are characterized for being agents that reduce lipogenesis and promote lipolysis. Gynoid lipodystrophy, commonly known as cellulite, is a multifactorial fatty tissue alteration perceived by the appearance of deformations in the skin similar to the ‘’orange peel’’ aspect. This skin disfunction can occur in any body region, however, it is more frequent in the glutes, thighs and abdomens regions, affecting manly the female population after

puberty. Fibroblasts alteration, manly caused by estrogen, creates structural modifications in the dermis glycosaminoglycans and in the perivascular connective tissue. This process causes water retention (edema), increases the interstitial matrix viscosity, produces cellular changes, and, consequently, compresses the vessels. Poor blood circulation leads to an alteration in glucose metabolism, which actives proline, increasing collagen production, resulting in tissue fibrosis.

Besides this, this process influences in the tissue’s microcirculatory capacity by increasing capillary pressure, with blood flow reduction. As a consequence, the accumulation of toxins, microhemorrhages and edema is observed, which are classic characteristics observed in regions with cellulite7. Caffeine’s lipolytic action is due to the mobilization of free fatty acids from tissues and intramuscular stores. It acts inhibiting the phosphodiesterase enzyme, in addition to antagonizing adenosine receptors, thus increasing levels of cyclic adenosine monophosphate. (cAMP), promoting lipolysis and, consequently, reducing measurements. Synergistically, the blood microcirculation activation reduces local swelling, and promotes toxins elimination. As a result, it is observed skin texture improvement, reducing the visible ripples of cellulite.

In the eyes region, the eyelids skin is very thin, and it is a region abundantly irrigated by blood vessels. Being the dark and swollen appearance of the periorbital region a common complaint among people, which is triggered by several factors, such as: caused by excess deposition of melanin and toxins, shadow effects, increase in vascularity and structural change related to age and hereditary characteristics. Caffeine has a vasoconstrictor action and is rich in antioxidants which help combat inflammation and remove toxins. These activities promote the appearance reduction of bags and whitening of the eyes region. Another beneficial caffeine activity is the fibroblasts stimulation by the increase in collagen synthesis and other components of the extracellular matrix, causing skin firmness increase.

This way, NV Caffeine ECO is a versatile and high-performance option, with greater stability and more effective permeation, and acts in the aging process by stimulating cell regeneration, actives blood circulation, reduces swelling, improves dark circles appearance and has a potent action in combating cellulite and localized fat.